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[9] Seen in disorders that cause increased arterial wall stress (e.g., hypertension, coarctation of the aorta) as well as connective tissue disorders (especially MFS and EDS) Can lead to aortic aneurysm and aortic dissection Histopathology Loss, thinning, disorganization, and fragmentation of elastic tissue in the media Accumulation of mucoid extracellular matrix Loss of smooth muscle nuclei Differential diagnoses Marfan syndrome classically manifests with a superior and temporal displacement of the lens (upward and outward)

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Below each area is then given the polygon's perimeter