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that when GHRP is administered in vivo at the same dose as GHRH, it releases more GH than the primary neuropeptide, demonstrating the dependence of GHRP upon GHRH for activity

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Activated PLC produces diacylglycerol (DAG) and inositol triphosphate (IP3) that leads to the release of Ca ++ from the endoplasmic reticulum