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Excessive ROS (1000 µM H 2 O 2 [57], 100 µM H 2 O 2 [58]) is reported to induce mutations of nuclear [59] and mitochondrial DNA [60], affecting the replication, proteins post-translation modifications [61], and membrane phospholipids [60] in the cardiac cells, accelerating aging and cell death [62]

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ASC, apoptosis-associated speck-like protein containing a CARD