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This primary (canalicular) secretion is further modified by cholangiocytes during its transit along bile ducts, as a result of a balance between hormone-dependent water and electrolyte secretion and, on the other hand, the obligatory absorption of water, electrolytes and organic solutes.48,49Figure 1 depicts the main solutes and transporters relevant to bile formation at both the hepatocellular and the bile-ductular levels
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