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Studies show the consuming an excessive amount of vitamin B12 may: Increase the risk of cardiovascular events in people with diabetic nephropathy : A study published in JAMA sought to determine whether B vitamin therapy was able to slow the progression of diabetic nephropathy (kidney damage due to diabetes) and prevent vascular complications

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NSI‐189‐treated stroke animals displayed significant increments in MAP2 density compared to vehicle‐treated stroke animals, which were more pronounced in the hippocampus than the cortex, in that the amplified MAP2 density in the cerebral cortex was only detected at the 12‐week period, whereas such increased MAP2 density was found in the hippocampus for both 12‐ and 24‐week time points ( p 's 0.05), further implicating the role of neurogenic factors in tandem with neurite outgrowth enhancement (Fig