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It was included 88 studies in this review ( N = 121,190) in 145 publications and observed a reduction in the LDL-c (-2.58 mg/dL [95% CI, -4.30 to -0.85] in 13 trials [ n = 5554]), and total cholesterol concentration (-2.85 mg/dL [95% CI, -4.95 to -0.75] in 19 trials [ n = 9325])