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This creates a vicious cycle of “damage accumulation and functional deterioration,” exacerbating oxidative stress, energy crisis, and cellular dysfunction, wherein failed clearance exacerbates the very oxidative stress and dynamics imbalance that generated the damaged organelles in the first place, ultimately promoting chondrocyte death and matrix degradation (59)
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Specifically, the relatively small sample size, the unbalanced male/female ratio (with a higher number of males in two of the three cohorts), and the short intervention period constrained our ability to assess the long-term effects of the Sucrosomial ® B12 formulation
