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Apart from mutations, other significant factors accounting for α-synuclein fibrillation are changes in pH of the microenvironment (Frey et al., 2024), presence of other metal ions temperature (Puspita et al., 2017), phosphorylation (Ghanem et al., 2022

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It is one of the non-bariatric risk factors for vitamin B12 deficiency that I sometimes find in patients