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Human β-defensin 3 significantly reduces the expression of icaA and icaD genes (accountable for biofilm production in Staphylococcus epidermidis ) while increasing the expression of the icaR gene (encoding for a transcriptional repressor of the ica operon expression), resulting in a significant attenuation of biofilm production (135)

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AOD-9604 has attracted interest because of its distinct amino acid structure and its role as a research compound in experimental settings