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Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions

An increase or decrease in a single matrix marker does not establish complete repair

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During reticulocyte maturation, lipid peroxidation mediated by 15-lipoxygenase in humans and rabbits and by 12/15-lipoxygenase (ALOX15) in mice was considered the initiating event for the elimination of mitochondria but is now known to occur through mitophagy