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Weeks 1-2: Metabolic Initiation During the first two weeks, the primary changes occur at the cellular level and may not be subjectively noticeable

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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5′-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable