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Doses tested were 250mg once daily, 250mg twice daily, and 500mg once daily and all three showed a statistically significant reduction in melanin index compared with placebo, measured using a handheld device called a mexameter

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The potency of NSAIDs in inhibiting PGHS-1 and PGHS-2 are often compared on the basis of their IC 50 values (the concentration of NSAIDs that inhibits 50% activity of the enzyme) in the in vitro assay system