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reported that the RyR channel from aged rodent muscle (24 months) was significantly oxidized with cysteine-nitrosylation and depletion of the channel stabilizing subunit calstabin1, compared to young muscles (3–6 months), and these oxidative remodeling resulted in leaky channels with increased intracellular Ca 2+ amount and impaired muscle force generation [162]

exfoliant

Size:10mg-Reconstituted

Nguyen NT, Umbaugh DS, Smith S, et al