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Expression of GGT In the rat, GGT is a single copy gene, and its expression is regulated by five tandemly arranged promoters that give rise to seven different transcripts, all of which encode the same protein but have distinct 5′-untranslated regions (UTRs) (Chikhi et al., 1999)
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Interestingly, itching that remains still a significant nuisance in atopic dermatitis could be potentially an aim for luteolin, as luteolin 7-methyl ether significantly decreased the TNF-α-induced TRPV1 expression and slightly diminished the expression of TRPA1 and IL-31 induced by the same cytokine as well [161]
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