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To ensure a broad and comprehensive analysis, studies included in this review were not limited to randomized controlled trials (RCTs) but also encompassed observational studies, cohort studies, and prospective trials that investigated selenium deficiency, selenium concentrations, or selenium supplementation in critically ill and trauma patients

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The isolated fraction induced delta-wave (slow-wave) sleep when injected into recipient animals — giving the peptide its name — and initiated one of the most distinctive research trajectories in neuropeptide biology: a compound with a clearly demonstrated biological name-property, an exceptionally wide pharmacological activity profile, and — nearly five decades later — a receptor that remains formally uncharacterised