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21,23,69,80,104,115 Polyethylene glycol (7 Å) and creatinine (6 Å) have been used as probes for the in vivo investigation of pore pathway permeability

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For example, a meta-analysis of 45 randomized controlled trials observed a trend toward increased risk of thyroid dysfunction in patients treated with GLP-1 receptor agonists, although the findings did not reach statistical significance