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Additionally, increased intestinal permeability, called leaky gut, allows gut-derived pro-inflammatory molecules and microbial metabolites to enter systemic circulation, enhancing systemic inflammation and influencing central neuroinflammatory processes (Fig
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Moreover, our proteomics data revealed the presence of several proteases and nucleases (Supplementary Data 2), which, if catalytically active, may lead to the liberation of amino acids and nucleosides from protein and RNA/DNA, respectively
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