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In a recent systematic review, results from 20 TNF-α inhibitor de-escalation studies (14 RCTs and six non-RCTS) determining the actual reduction in the occurrence of adverse events when de-escalating the existing therapy in different inflammatory conditions, such as psoriasis, axSpA, RA, and IBD, were summarized

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While investigation into its clinical applications is ongoing, it is becoming an increasingly discussed component of regenerative wellness protocols because of its potential to complement other recovery-focused therapies