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However, once a multi-dose pen is first used, the in-use period (discussed in the next section) takes precedence over the printed expiration date

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Calcification of the CEP leads to a reduction in the nutrient supply to the IVD, further exacerbating the progression ( FIGURE 2 The structural hallmark of IDD is the progressive dehydration of the NP mainly due to the gradual loss of proteoglycans within the ECM ( 4.1 Inflammatory reaction IDD is closely related to inflammatory reaction