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Recent study has shown that the co-administration of Sildenafil (SD) and simvastatin (SV), NO donor/BH4 regulator, inhibits the cranial irradiation-induced oxidative stress, inflammation, NO-pathway dysregulation and neuronal apoptosis, indicating a neuroprotective effect role of SD/SV in irradiation-induced brain injury as a possible mechanism of its NO donor/BH4 regulatory activities (102)