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Mechanism of actions of cholecystokinin receptors revealed
To further verify that the catalytic activity of LOXL2 was responsible for the increase in BHZ signal, we used the following negative controls: (1) the overexpression of catalytically inactive H626/628Q LOXL2 double mutant (LOXL2-DM) 39,40 , (2) inhibition of LOXL2 specific activity using the small molecule inhibitor PAT-1251 (10 µM) in cells overexpressing catalytically active LOXL2 41 , and (3) inhibition of total LOX activity using the non-selective small molecule LOX inhibitor β-Aminopropionitrile (BAPN
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For example, tumor cells can evade immune surveillance not only through the PD-L1/PD-1 pathway but also by suppressing T cell function through other immune checkpoints such as TIM-3 and CTLA-4 (183, 184)
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