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For cagrilintide itself, the slowing is inferred from amylin receptor pharmacology and from the gastrointestinal adverse events recorded in its obesity trials — a dedicated human gastric-emptying study on cagrilintide has not been published to date

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GLP-1 receptor activation reduces appetite, slows gastric emptying, promotes insulin secretion from pancreatic beta cells, and creates the characteristic feeling of fullness that GLP-1 agonist users report