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Effects of iron excess on cell viability and mitogen-activated protein kinase activation in rice roots

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Vascular endothelial injury and microcirculation dysfunction Cytokines such as TNF-α and IL-1β target endothelial cells, upregulating the expression of adhesion molecules (E-selectin and VCAM-1) and disrupting tight junctions, which increase vascular permeability and promote edema [89]