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Oral cimetidine gives effective symptom relief in painful bladder disease: a prospective, randomized, double-blind placebo-controlled trial

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Apart from low doses, when opting for protocols with weekly macrodoses of supplementation or booster doses, we must provide a very high intake of B12 to ensure that we cover the absorption of a small but sufficient fraction, even at the expense of the vast majority of the B12 in the supplement not being utilized and being eliminated due to the lower absorption efficiency found with this route, as it is not dependent on the intrinsic factor