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Semaglutide produced less weight loss than tirzepatide head-to-head, about 14% versus 20%.² Its body-composition substudy measured a roughly 62:38 fat-to-lean loss split by mass, compared with about 75:25 for tirzepatide in a separate trial.⁵ The scan overstates muscle loss because lean mass includes water and organ tissue

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[4] [5] By activating GLP-1 receptors, retatrutide is thought to enhance insulin secretion in a glucose-dependent manner, suppress glucagon release, and reduce appetite by acting on satiety centres in the brain