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Proton-coupled monocarboxylate transporters (MCTs) facilitate lactate and proton extrusion, alleviating pH-dependent inhibition of phosphofructokinase 1 (PFK1) to sustain glycolytic abundance (97)

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Clinical Development and Human Studies Following promising preclinical results, AOD9604 entered human clinical trials to evaluate safety, tolerability, and efficacy in overweight and obese populations