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Abbreviations AASLD: American Association for the Study of Liver Diseases ABCA1: ATP-binding cassette A1 ABL: abetalipoproteinemia ACAT: acetyl-coenzyme A acetyltransferase ALT: alanine transaminase ApoB: apolipoprotein B AST: aspartate transferase BMI: body mass index CESD: cholesterol esterase storage disease DNA: deoxyribonucleic acid DNL: de novo lipogenesis ER: endoplasmic reticulum FDA: Federal Drug Administration FFAs: free fatty acids FHBL: familial hypobetalipoproteinemia GCKR: glucokinase regulator HbA 1c : hemoglobin A1c HCC: hepatocellular carcinoma HDL: high-density lipoprotein HMCGCoA-R: 3-hydroxy-3-methylglutaryl-CoA reductase IR: insulin resistance IU/L: international units per liter LAL: lysosomal acid lipase LALD: lysosomal acid lipase deficiency LDL: low-density lipoprotein LDL-R: low-density lipoprotein receptor LXRs: liver X receptors MRI: magnetic resonance imaging MRI-PDFF: magnetic resonance imaging proton density fat fraction MTTP: microsomal triglyceride transfer protein NAFL: nonalcoholic fatty liver NAFLD: nonalcoholic fatty liver disease NAS: nonalcoholic fatty liver disease activity score NASH: nonalcoholic steatohepatitis OR: odds ratio PNPLA3: palatine-like phospholipase domain-containing-3 RUQ: right upper quadrant SREBPs: steroid regulation binding proteins TG: triglycerides TM6SF2: transmembrane 6 superfamily member 2 VLDL: very low-density lipoprotein WD: Wolman disease Declarations Acknowledgement The support of the Herman Lopata Chair in Hepatitis is gratefully acknowledged