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Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury

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inhibits lipogenesis Primary MOTS-c mechanism / activates AMPK, improves glucose uptake, reduces insulin resistance Key AOD-9604 animal finding / 50 mcg/kg/day reduced adiposity 50% in obese mice (Heffernan 2001) Key MOTS-c animal finding / 15 mg/kg/day prevented diet-induced obesity and reversed insulin resistance in mice (Lee 2015) Regulatory status / both are unapproved research peptides

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