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An indicator based on disease burden such as the disability-adjusted life year (DALY) would be no more complex than overall prevalence (i.e., it is a one-dimensional metric), but it better reflects the impact that the disease has on the population

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In general, two reactions can occur: (1) a disproportionation reaction in which GSH is converted to GSSG with concomitant elimination of the xenobiotic substituent (RH) (Eq