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For FRAA-positive participants, improvement in verbal communication was significantly greater in those receiving folinic acid as compared with those receiving placebo, resulting in an effect of 7.3 (1.4,13.2) standardized points with a large effect size (Cohen’s d =0.91), indicating that folinic acid treatment may be more efficacious in children with ASD who are FRAA positive

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But it’s important to address what’s injuring your esophagus