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Among the proteins, interleukin-8 (IL-8) (12), macrophage migration inhibitory factor (MIF) (13), galectin-1 (14), MK (15), IL-18 (16), galectin-3 (17), HDGF (18), osteopontin (OPN) (19), connective tissue growth factor (CTGF) (20) and GRN (21) are known to be involved in angiogenesis besides VEGF-A
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