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E2 appears to mediate many of these changes through rapid effects on HDL-C elevation (e.g., via reduced hepatic lipase activity) and longer-term reductions in TC and LDL-C (e.g., via upregulated LDL receptors), whereas P4 may exert counter-regulatory or anti-estrogenic actions [132]

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In this experiment, the skin was treated topically with 2 μM peptides along with LPS for 14 days