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This hypothesis was confirmed by a study of Gong and co-workers in Cd-treated Arabidopsis [75]

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tGSH levels were (a) significantly decreased in young relative to old adults (Nuttall et al., 1998), (b) significantly decreased in young adults (27–35 yrs) compared to young to middle-aged (36–57 yrs) (Kretzschmar et al., 1991), while (c) no significant differences were observed between middle-aged to old (55–70 yrs) and old (70–85 yrs) adults (Andriollo-Sanchez et al., 2005)