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Cells drop into senescence in increasing amounts as we age, and it’s one of the leading theories on why humans grow old and die — eventually, the number of cells that are dividing and renewing the body drop in proportion to the number of cells in senescence, leading to higher and higher numbers of dysfunctional cells (that can cause cancer or inflammation), and the human body degrades until it can no longer function and we die

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Janeway’s Immunobiology , 8th edn