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Biochem Biophys Res Commun (2008) 372(2):314–9

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Metabolomic and lipidomic approaches have elucidated numerous circulating lipids that are directly associated with the severity of COVID-19, indicating that lipid metabolism could be a potential target for therapeutic strategies in the treatment and management of the disease ( As bioactive lipid metabolites of phosphatidylcholines (PCs), plasma lysophosphatidylcholines (LPCs) are primarily generated by the action of secretory phospholipases A2 (sPLA2) following the removal of a fatty acid ( ex vivo lung perfusion model ( Those decreased LPCs containing unsaturated acyl groups such as LPC 20:0 might impact the host’s immune or inflammatory responses by affecting the interaction with NKT cells, GCSF, and IL-6, and then lead to unfavorable outcomes