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This further promotes an autoamplification loop that exaggerates inflammation and cell death and leads to a more severe degree of cell death and a range of inflammation-related responses [95, 96]
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In human studies, long-term recreational ketamine use has been associated with structural brain changes, including reduced prefrontal gray matter volume and impaired white matter connectivity, which are potentially linked to chronic low-grade inflammation (Liao et al., 2011
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