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However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007

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University of Texas Medical Branch (UTMB) and University of Texas at San Antonio Amino acid sequence Not applicable — 5-Amino-1MQ is a small-molecule NNMT inhibitor (a methylquinolinium compound), not a peptide