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Histidine-containing sequences have well-documented affinity for copper(II) ions, which may support the compound's ability to deliver bioavailable copper to follicle tissue when applied topically — though the extent of percutaneous penetration of intact peptide-copper complexes into the scalp remains an area where more human data would be valuable

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Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice