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7 Summary and prospects In the development of DCM, 4-HNE, a key product of LPO, plays a pivotal pathogenic role

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This is evident by the late induction of both p-γH2AX and γH2AX [45], concomitant with the suppression of ATM, pS1981-ATM, RIF1, and pT68-Chk2, all components of the DNA damage response [46,47,48]