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Dietary AGEs combined with CRS exposure disrupted intestinal barrier function, exacerbated intestinal inflammation and disturbed TRP metabolism Compared with the MCON group, the protein expression of occludin ( P = 0.047) and ZO-1 ( P = 0.043) in the colon from MCRS group were significantly decreased, and the protein expression of occluding ( P = 0.01), claudin 1 ( P = 0.03), and ZO-1 ( P = 0.01) in the colon of mice from the MCRA group were all significantly reduced, with a further decrease in claudin 1( P = 0.03) protein expression in the MCRA group compared to the MCRS group (Fig
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Carter BZ, Mak PY, Mu H, Mak DH, Dettman EJ, Cardone M, Wang X, Schober W, Tao W, Seki T, Andreeff M
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