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Frontiers | A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease
Since mitochondria is the primary site of ROS production, cisplatin-induced oxidative stress often leads to abnormal mitochondrial calcium uptake, mitochondrial membrane depolarization and decreased ATP synthesis, eventually activating the apoptotic pathway [1,36](Figure 1)
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