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Modifiers that increase β-cell cAMP, such as forskolin, induce expression of the second subunit yielding functional activity of GABABR (decreasing insulin secretion) ( Autocrine and paracrine mechanisms account for the regulatory actions of ambient GABA on β- and α-cell function ( Rodent and human islet studies demonstrate the complex autocrine and paracrine signaling that underpin nutrient-responsive crosstalk amongst α-, β- and δ- cells
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