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Our analysis of the multinutrient responder and multinutrient non-responder groups identified the cytokine–cytokine receptor interaction pathway as most relevant ( p = 6.6 × 10 −6 ), incorporating five of the previously identified six immune factors that showed a differential signal of change over time between these groups (i.e., IL-1RA, IL-6, IL-15, IFN-γ, and leptin