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We combined proximity-labelling-based proteomics, biochemistry and high-resolution microscopy to unravel a lysosomal membrane regeneration pathway that depends on ATG8, the lysosomal membrane protein LIMP2, the RAB7 GTPase-activating protein TBC1D15 and proteins required for autophagic lysosomal reformation, including dynamin-2, kinesin-5B and clathrin

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The stress kinases in turn phosphorylate eukaryotic initiation factor 2α (eIF2α) and the collective effects of eIF2α activation is termed the ISR 14