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Wang et al., 2020), a recent report suggests that propionate increases the expression of ZO-1 and occludin, thereby improving intestinal epithelial integrity by a serine-threonine kinase (AKT) signaling pathway ( Faecalibacterium prausnitzii , which plays a critical role in maintaining immune homeostasis by inhibiting the NFκB signaling pathway and cytokine production and increasing colonic epithelial tight junction proteins, is significantly reduced in both IBD and PD (Lopez-Siles et al., 2016