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Of note, a ferroptosis independent study indicated that necrotic or regulated necrotic cell death routines and not apoptosis primarily drive cell death upon liver tissue upon IRI, as proven by the presence of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) positivity, absence of active caspase-3 staining and ineffective treatment with caspase inhibitors [506]