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Animal Models of Nicotine-Induced Gastric Damage In a series of rat experiments published between 1993 and 2005, Sikiric's laboratory showed that oral and subcutaneous BPC-157 at doses of 10 ng/kg to 10 mcg/kg prevented and healed cysteamine-induced duodenal ulcers and ethanol-induced gastric lesions with near-complete protection at higher doses [8]