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Their action signals the cell to modulate its response, through the recruitment of endogenous coping mechanisms, among which are an increased synthesis of antioxidants and of electrophile quenchers, the transcription of the necessary gene products and the production of reducing cofactors such as NADH/NADPH and ascorbate

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1 Roughly 85% of all lung malignancies are non-small cell lung cancers (NSCLC), which mostly consist of adenocarcinoma (AdC) and squamous cell carcinoma (SCC) histotypes