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The T1D-associated SNP at rs763361 increases VAV1 phosphorylation and subsequent IL-17 signaling, which is involved in T1D pathogenesis, in CD4+ T cells, suggesting an increased functional variant (93)

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Sample preparation : Tissue: Accordance ratio Tissue weight (g): Extract solution (mL)=1:5~10 (Suggested 0.05g of tissue with 1mL of Extract solution), homogenate on ice bath