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Two mechanisms dominate the working model proposed by the research group most associated with this peptide (P

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1 Urinary frequency is often the first symptom of IC to arise, but patients may not recognize it as a problem until they have endured many years of it.5 Among patients with IC, 92% report urinary frequency: 86% say that they urinate more than 11 times during a 24-hour period and 71% say that they urinate 3 or more times at night—the definition of nocturia